Like the Spybot Search and Destroy tool I highlighted in the previous edition of CAD Manager's Toolbox, Malwarebytes' Anti-Malware software is a great weapon in your battle against malicious computer worms and spyware.
The free version of Anti-Malware provides thorough scanning and removal tools, along with a constantly updated set of signature files to keep you current. The full version ($24.95 per license) adds automatic detection, scheduled scanning, and malicious site blocking based on the list of signature files.
All you need to do is download the required files from the Malwarebytes web site and run through the installation procedure, and you'll be on your way to detecting infections. As with any virus or malware tool, it usually pays to keep a copy of the installation and the latest update files on a memory stick or disk so you can install to an infected machine that is detached from the Internet. I've also found Anti-Malware works well when machines are booted into Safe Mode.
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